Ya, I can't really think of anyone more persistent and pernicious than McCarthy. VenomFangX gets the "Ms Congeniality" prize for being forced to apologize to Thunderf00t (
clicky).
Of course I vote Tyson as
Guest of the Year, but I would have said that even if he was never on the show...
I think the coolest news story of the year is the one you're going to talk about later today: We've seen extrasolar planets!!! The only other thing that could compete in my heart (the LHC) broke :'(
(but it'll be 'coolest news story of 2009,' I'm sure

).
I really liked the live shows, and all the interviews at TAM were great. If I wasn't such a Tyson fanboy, I'd have to call
Guest of the Year for George Hrab (ep157).