#259: I mainly just like the way they interact in this episode, and there are also some funny parts.
This is tough, but I narrowed it down to Massimo Pigliucci and Eugenie Scott.
It's hard to choose, but I think this gets my vote for funniest:
#250: Jay's inspiring quote becomes "the most horrible thing known to mankind" 01:14:56 to 01:17:20
#238: It turned out to be cracking ice sheets but sounds like the lasers in Star Wars.
#238: Evan says, "Isn't that nice that this movie has taken the good name of skeptic and turned it into an 8% on rotten tomatoes?" 24:19 to about 24:27
Best Science news story of the year
The LHC ALICE experiment mentioned in episode #278.
Most outrageous illogical statement or pseudoscientific claim
70 years without food/water
Most unexpected scientific discovery
The galactic "bubbles"
Most unbelievable but true Science or Fiction story
The sea slug that makes its own chlorophyll. Very cool.
Jackass of the Year
Oprah for promoting the psychic surgeon.
Skeptic of the Year
OK, so I was listening through the 2010 episodes trying to find my favorite quote and the funniest quote, and I decided to include several that I found amusing. I realize that not all of them will be used, but maybe this list will also help other people decide.
#238: Dr. Steve does an impression of Sagan saying "primordial soup" at 01:10:15
#240: Jay in Sci or Fi. 01:01:12 to about 1:03:05
#248: Rebecca talks about the ICP song that includes that line about magnets and talks about how she explained the creation of rainbows to a juggalo. 22:32 to about 24:35
#251: They reminisce at the beginning and then play back the original episode where Bob says "Hellloooooo" 01:35 to 03:09. "Expunge that from your hard drive!" They also tease Bob about it from 01:17:32 to about 01:17:54
#252: Human/chimp relations, Rebecca calls Steve a perv. 00:27:56 to about 00:28:46
#260: George Hrab is introduced and mimics Bob's "Hellooooo" 02:39 to 03:03
#259: sci or fic from 01:09:34 to 01:10:35, and the other rogues give Jay a hard time for flubbing the quote: 01:16:10 to 01:16:29
#262: Jay in sci or fic, including funny quip from Evan. 01:02:39 to 01:03:22