I dont have time to watch that whole video, but I will read one of his papers and get back to you. It certainly seems like there is enough evidence to say eating too much sugar is bad for you, but there were a few red flags in the new york times magazine article on this topic. For one, I never like it when several conditions are linked to the same thing, especially when cancer is one of those things. The other thing is that there really isn't a lot of research on this topic in humans, most of it is rats. You can find almost exactly the same type of articles about high glycemic index foods, but fructose is a low glycemic food.
But perhaps the biggest red flag of them all is the silver bullet concept. I really doubt anything so complex as the things Lustig discusses can be boiled down so easily to one food.