« Last post by stands2reason on February 26, 2017, 09:03:09 PM »
I must be missing something. Doesn't it take several hours for your memory B cells to recognize and start triggering antibody production? Wouldn't something like a malaria sporozoite, or West Nile RNA have gotten out of the tiny bolus of saliva in that time? Usually you have to mount an immune response before the target agent takes up residence in its target organ/cell, but this is shrinking the window quite a bit.
I think that the allergies more likely develop from more mundane pathogens present in the insect saliva. Any puncture will put some weak environmental bacteria in your body. After getting infected once (or a few times) by anything, the immune cells correlate the prescience of the saliva protein and then will later react to it.