Author Topic: The AGS-v mosquito vaccine  (Read 318 times)

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Offline stands2reason

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The AGS-v mosquito vaccine
« on: February 25, 2017, 10:06:36 AM »
Just heard about this on the CBS morning news.

http://www.cbsnews.com/videos/morning-rounds-rare-diseases-kids-healthy-eating-trial-vaccine/

https://arstechnica.com/science/2017/02/one-vaccine-to-wipe-out-all-mosquito-borne-disease-its-in-clinical-trials/

https://www.nih.gov/news-events/news-releases/nih-begins-study-vaccine-protect-against-mosquito-borne-diseases

It sounds like they are trying a novel approach to fighting mosquito-borne illness. Their novel idea is to treat the mosquito saliva itself as an antigen. This means the immune system will go trained to treat mosquito saliva as an antigen, meaning it goes into a heightened state (or attack mode) whenever it detects mosquito saliva. This should put your system on guard for whatever is in the mosquito saliva.

This is what concerns me: it sounds like they effectively condition the immune to system have an allergic reaction (heightened immune response) to something that is not actually a pathogen (mosquito saliva).

This is a trial, so there are still open questions.

-An immune system response (inflammation and auto-phagy) doesn't have zero cost, so wouldn't this be deleterious to health?
-Wouldn't this make it more likely for someone to have anaphylaxis, a strong allergic reaction with things like trouble breathing, to a mosquito bite?
-Will this teach us anything about insect bite allergies?



Online Sawyer

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Re: The AGS-v mosquito vaccine
« Reply #1 on: February 25, 2017, 05:44:38 PM »
I must be missing something.  Doesn't it take several hours for your memory B cells to recognize and start triggering antibody production?  Wouldn't something like a malaria sporozoite, or West Nile RNA have gotten out of the tiny bolus of saliva in that time?  Usually you have to mount an immune response before the target agent takes up residence in its target organ/cell, but this is shrinking the window quite a bit.

Offline stands2reason

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Re: The AGS-v mosquito vaccine
« Reply #2 on: February 26, 2017, 09:03:09 PM »
I must be missing something.  Doesn't it take several hours for your memory B cells to recognize and start triggering antibody production?  Wouldn't something like a malaria sporozoite, or West Nile RNA have gotten out of the tiny bolus of saliva in that time?  Usually you have to mount an immune response before the target agent takes up residence in its target organ/cell, but this is shrinking the window quite a bit.

I think that the allergies more likely develop from more mundane pathogens present in the insect saliva. Any puncture will put some weak environmental bacteria in your body. After getting infected once (or a few times) by anything, the immune cells correlate the prescience of the saliva protein and then will later react to it.

 

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